A rhein-integrated hydrogel dressing with antibacterial, antioxidant and pH-responsive colorimetric properties

RSC Advances 2026 Open access

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Authors: Miaoshen Kou, Deng Wang, Jiawei Zhang, Fangzheng Yu, Yang Yuan, C Y Wang, Jiale He, Zheng Zhao, Ying Liu
DOI: 10.1039/d6ra03047e
Cited by: 1
References: 38

Abstract

(MRSA). It also exhibited strong antioxidant activity, with an ABTS radical scavenging rate of 87.22% and effective reduction of intracellular ROS accumulation. In addition, the hydrogel showed a distinct pH-dependent colorimetric response over the wound-relevant pH range of 5.5-7.5, allowing visual indication of local pH variations. The SF/HA/Rhe hydrogel further displayed favorable mechanical performance and biocompatibility, with cell viability above 90% and hemolysis below 5%. Overall, these findings provide a feasible strategy for multifunctional hydrogel dressings with integrated antibacterial, antioxidant and visual pH monitoring.

Fields of Study & Subjects

Wound Healing and Treatments Hydrogels: synthesis properties applications Nanoplatforms for cancer theranostics

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
31
Pages
28092–28102
Publication date
1 January 2026
Language
EN