α-Alkylated α-amino acids reduce the aggregation of unfolded peptides
Abstract
Aberrant aggregation complicates the development of bioactive peptides. Here, we generate new α-ethylated variants of proteinogenic amino acids and demonstrate that they reduce peptide aggregation through a mechanism distinct from their α-methylated counterparts. Whereas α-methylated residues reduce aggregation by favoring helix formation, α-ethylated residues prevent aggregation without promoting secondary structure.
Fields of Study & Subjects
Supramolecular Self-Assembly in Materials
Chemical Synthesis and Analysis
Origins and Evolution of Life
Publication details
- Journal / source
- RSC Advances
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 16
- Issue
- 33
- Pages
- 30200–30204
- Publication date
- 1 January 2026
- Language
- EN