Design, synthesis, and biological evaluation of novel imidazole–morpholinone hybrids as broad-spectrum antimicrobial agents: molecular docking, DFT, and ADMET studies

RSC Advances 2026 Open access

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Authors: Amrish J. Dave, Sweta S. Joshi, Jay B. Maheta, Yogesh O. Bhola, Jatin Upadhyay
DOI: 10.1039/d6ra03352k
Cited by: 1
References: 22

Abstract

GyrB24 (7P2M), corroborated by DFT analysis (B3LYP/6-311++G(d,p)) and ADMET profiling, confirmed DNA gyrase inhibition as the primary mechanism and established 10c as a promising drug-like lead for further development.

Fields of Study & Subjects

Cancer therapeutics and mechanisms Synthesis and biological activity Synthesis and Reactivity of Heterocycles

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
32
Pages
29867–29883
Publication date
1 January 2026
Language
EN