Pepholin, a bacteriophage holin-derived antimicrobial peptide with membrane-disruptive activity and therapeutic efficacy in MDR Pseudomonas aeruginosa burn wounds

RSC Advances 2026 Open access

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Authors: Purushotham RV, Sameer Shrivastava, Sonal Saxena, Sabapathi Nagappan, Pradeep Kumar, M. Saminathan, Abhinav Kumar, Sanjay Kumar Singh, Satyabrata Dandapat
DOI: 10.1039/d6ra03599j
Cited by: 1
References: 98

Abstract

. Topical treatment significantly enhanced bacterial clearance, accelerated wound healing, promoted collagen deposition, and modulated cytokine responses. Collectively, these findings demonstrate that bacteriophage holin derived peptides represent a promising new class of antimicrobial agents and establishes Pepholin as a stable, biocompatible, and mechanistically defined AMP with dual antimicrobial and wound-healing activity, supporting its development as a next-generation therapeutic for infected wound management.

Fields of Study & Subjects

Antimicrobial Peptides and Activities Antimicrobial agents and applications Bacteriophages and microbial interactions

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
37
Pages
39479–39504
Publication date
1 January 2026
Language
EN