Chemically stabilized MgF 2 –Ag–Al 2 O 3 SPR biosensor for label-free brain tumor detection

RSC Advances 2026 Open access

Read full text
Authors: Walaa M. Nouman, Arafa Hussein Aly, Fatma A. Sayed, S.E.-S. Abd El-Ghany, Samira M. Sallam
DOI: 10.1039/d6ra03966a
Cited by: 1
References: 45

Abstract

coating protects the silver layer from oxidation, improving long-term stability while preserving strong optical performance. In addition, its surface chemistry supports future biofunctionalization. Temperature analysis at 25 °C and 37 °C shows measurable changes in the SPR resonance angle due to the negative thermo-optic response of biological tissues. These findings indicate that the proposed SPR platform could serve as a rapid, sensitive, and clinically relevant tool for distinguishing healthy, primary tumor, and metastatic brain tissues.

Fields of Study & Subjects

Advanced biosensing and bioanalysis techniques Nanoparticle-Based Drug Delivery Nanoplatforms for cancer theranostics

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
35
Pages
36163–36176
Publication date
1 January 2026
Language
EN