Lipid-donor-anchored genome mining uncovers dioxanopeptins, antibacterial lipopeptides with a 1,3-dioxane functionalized polyunsaturated lipid tail

Chemical Science 2026 Open access

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Authors: Ying Chen, Yunsheng Chen, Hao Xiang, Changqi Luo, Jiaqi Duan, Kun Hu, Xiaohong Zheng, Jing Liu, Yongbo Xue, Yi‐Ming Shi
DOI: 10.1039/d6sc00003g
Cited by: 2
References: 36

Abstract

, and their antibacterial phenotype correlated with disruption of proton motive force homeostasis and ATP production. Removal of the pyruvyl-derived ketal markedly diminished potency, highlighting its contribution to antibacterial activity. Together, these results expand the chemical space of lipopeptides and illustrate how lipid-donor-anchored genome mining can complement NRPS-focused strategies to access functionally differentiated antibiotic scaffolds.

Fields of Study & Subjects

Antimicrobial Peptides and Activities Microbial Natural Products and Biosynthesis Bacterial Genetics and Biotechnology

Publication details

Journal / source
Chemical Science
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
16
Pages
8229–8241
Publication date
1 January 2026
Language
EN