Chimeric peptide-based radiopharmaceuticals for glioblastoma imaging and therapy by targeting mHsp70 and enhancing BBB penetration

Chemical Science 2026 Open access

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Authors: Franziska Schuderer, Ruben Silva, Catarina G. Pinto, Lena Köller, Stefan Stangl, Lurdes Gano, Marco Cavaco, Miguel A. R. B. Castanho, Filipa Mendes, Susanne Kossatz, João D. G. Correia, Angela Casini
DOI: 10.1039/d6sc00011h
Cited by: 1
References: 65

Abstract

Glioblastoma (GBM) is the most aggressive form of malignant brain cancer. We designed chimeric peptide-based radioligands that cross the blood-brain barrier and target GMB.

Fields of Study & Subjects

Heat shock proteins research Peptidase Inhibition and Analysis S100 Proteins and Annexins

Publication details

Journal / source
Chemical Science
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
29
Pages
14222–14236
Publication date
1 January 2026
Language
EN