Chemoproteomics unveils the antibacterial mechanism of silver ions: inhibiting peptidoglycan synthesis via targeting Mur family proteins in Staphylococcus aureus

Chemical Science 2026 Open access

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Authors: Li-run Zhou, Ying Zhang, Yajian Li, Tong Yang, Zheng Chu, Qianyu Zhang, Hechen Tang, Ang Ma, Peng Gao, Chen Wang, Yin‐Kwan Wong, Cui Liu
+5 more Shengnan Shen, Junzhe Zhang, Qiaoli Shi, Huan Tang, Jigang Wang
DOI: 10.1039/d6sc00255b
Cited by: 1
References: 44

Abstract

exhibits a low resistance frequency compared to conventional antibiotics, underscoring its potential as an effective antimicrobial agent. Its distinct mechanism of action and reduced likelihood of resistance development indicate that it may serve not only as an effective therapeutic strategy, but also as a probe for elucidating the mechanism of bacterial peptidoglycan biosynthesis. These results offer new insights for the development of antibiotics targeting Mur family proteins.

Fields of Study & Subjects

Antimicrobial Peptides and Activities Antimicrobial agents and applications Peptidase Inhibition and Analysis

Publication details

Journal / source
Chemical Science
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
32
Pages
15298–15313
Publication date
1 January 2026
Language
EN