Enantioselective organocatalytic radical alkylation enabled by photoexcitation

Chemical Science 2026 Open access

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Authors: Yanji Song, Ruifeng Wang, Xi Lu, Yuqiao Zhou, Xiaoming Feng, Weidi Cao, Xiaohua Liu
DOI: 10.1039/d6sc00272b
Cited by: 1
References: 96

Abstract

without additional photocatalysts. The mechanistic studies reveal that the guanidine catalyst and phosphine benefit the formation of an excited enol reductant and an NHPI oxidant for electron transfer, respectively, and the chiral bifunctional catalyst also provides an H-bond network to guide outer-sphere radical coupling in an enantioselective manner.

Fields of Study & Subjects

Radical Photochemical Reactions Organoboron and organosilicon chemistry Catalytic C–H Functionalization Methods

Publication details

Journal / source
Chemical Science
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
22
Pages
11010–11016
Publication date
1 January 2026
Language
EN