Electrochemical control enables high-concentration, one-pot macrolactonization
Abstract
dual-mediation system, this method provides access to 5- to 21-membered lactones and accommodates O-, S-, and N-heteroatom functionalization. Its efficacy originates from the gradual, charge-consumption-dependent formation of an acyloxyphosphonium intermediate, which maintains a relatively low local concentration despite high substrate loading.
Fields of Study & Subjects
Radical Photochemical Reactions
Synthetic Organic Chemistry Methods
Chemistry and Chemical Engineering
Publication details
- Journal / source
- Chemical Science
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 17
- Issue
- 15
- Pages
- 7629–7635
- Publication date
- 1 January 2026
- Language
- EN