Photoinduced deacylative epoxidation of ketone derivatives with allylic peroxides

Chemical Science 2026 Open access

Read full text
Authors: Jiangtao Lin, Mingqian Zhou, Ziyang Li, Jiang Duan, Xiaoyu Liu, Y P Wang, Chao Shu
DOI: 10.1039/d6sc00898d
Cited by: 5
References: 55

Abstract

the photoinduced radical cyclization of ketone-derived pro-aromatic dihydroquinazolinones. This system operates under very mild conditions and showcases a broad substrate scope with excellent functional group tolerance (over 50 examples). Its gram-scale preparation and late-stage transformations emphasize its potential in drug discovery. A possible mechanism has been proposed based on mechanistic studies.

Fields of Study & Subjects

Radical Photochemical Reactions Oxidative Organic Chemistry Reactions Photopolymerization techniques and applications

Publication details

Journal / source
Chemical Science
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
21
Pages
10623–10631
Publication date
1 January 2026
Language
EN