Recent progress on Ni-catalysed alkyl–alkyl cross-coupling enabled by asymmetric hydrofunctionalization of alkenes
Abstract
) coupling. By exploiting readily available alkenes as coupling partners, these transformations enable rapid molecular saturation with enantioselectivity control under mild conditions. This review systematically summarizes recent advances in Ni-catalysed alkyl-alkyl coupling enabled by hydroalkylation of alkenes, with an emphasis on strategy development, mechanistic elucidation, and synthetic applications. Despite notable progress, challenges remain in further expanding substrate scope, enhancing catalytic efficiency, and refining mechanistic understanding to advance the synthetic utility of this strategy.
Fields of Study & Subjects
Catalytic C–H Functionalization Methods
Catalytic Cross-Coupling Reactions
Cyclopropane Reaction Mechanisms
Publication details
- Journal / source
- Chemical Science
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 17
- Issue
- 26
- Pages
- 12676–12704
- Publication date
- 1 January 2026
- Language
- EN