Ammonia monooxygenase: a work in progress
Abstract
OH, the structure and genetic underpinnings of this chemical behavior vary significantly. Further, there are many Cu-binding sites in AMO, and consequently there has been substantial discussion regarding the nature of the Cu site or sites responsible for substrate activation. Overall, AMO has largely eluded direct study because active protein has only recently been purified due to difficulties in cultivation of the native organism and recalcitrance of the protein to recombinant expression. This review is intended to serve as a primer to AMO, yielding the necessary context to understand its importance.
Fields of Study & Subjects
Bacterial Genetics and Biotechnology
Metal-Catalyzed Oxygenation Mechanisms
Metalloenzymes and iron-sulfur proteins
Publication details
- Journal / source
- Chemical Science
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 17
- Issue
- 18
- Pages
- 8934–8958
- Publication date
- 1 January 2026
- Language
- EN