Rhodium-catalyzed enantioselective intermolecular C–H silylation of simple arenes: synergistic substituent effects overcome silane redistribution to enable synthesis of Si-stereogenic arylsilanes
Abstract
The non-directed intermolecular C-H bond silylation has manifested itself as a versatile tool for the synthesis of organosilicon compounds; however, the corresponding asymmetric transformations remain elusive, primarily due to the facile self-reactions of silane reactants. Herein, we disclose an efficient protocol that involves steric-hindrance-enabled, Rh-catalyzed enantioselective intermolecular C-H bond silylation of simple arenes to deliver a broad array of Si-stereogenic monohydrosilanes in good yields with excellent enantioselectivities (up to 99% ee), featuring readily available starting materials, simple synthetic operations and mild reaction conditions.
Fields of Study & Subjects
Catalytic C–H Functionalization Methods
Organoboron and organosilicon chemistry
Cyclopropane Reaction Mechanisms
Publication details
- Journal / source
- Chemical Science
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 17
- Issue
- 31
- Pages
- 15050–15055
- Publication date
- 1 January 2026
- Language
- EN