Reversible one-step acylation facilitates mitochondrial delivery of functional RNA

Chemical Science 2026 Open access

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Authors: Yuli Zhuang, Xia Liu, Yuxuan Shen, Qiuyue Wang, Zhimin Lin, Qian Zeng, Xin Chen, Linye Jiang, Shao Yao, Jingyan Ge
DOI: 10.1039/d6sc01497f
Cited by: 1
References: 40

Abstract

delivery of siND1 selectively suppresses MTND1 expression without affecting MTCO1 and significantly inhibits tumor growth in a xenograft model. Conclusively, this work establishes reversible RNA acylation as a simple and versatile chemical framework for mitochondrial RNA delivery and therapy.

Fields of Study & Subjects

Mitochondrial Function and Pathology RNA Interference and Gene Delivery RNA and protein synthesis mechanisms

Publication details

Journal / source
Chemical Science
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
30
Pages
14603–14612
Publication date
1 January 2026
Language
EN