Asymmetric hydrogenation of 3 H -azepines via catalytic kinetic resolution: access to anti -disubstituted azepanes

Chemical Science 2026 Open access

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Authors: Linda Bui, Dilara Berna Yildiz, Diego García Matesanz, Esteban Matador, Raquel Sanchez, Iuliana L. Atodiresei, Giovanni Lonardi, Daniele Leonori
DOI: 10.1039/d6sc01819j
Cited by: 1
References: 45

Abstract

Azepanes are increasingly valued scaffolds in drug discovery, yet general asymmetric methods for their synthesis remain elusive. Herein, asymmetric hydrogenation of 3 H -azepines affords anti-configured azepanes with excellent diastereo- and enantioselectivity.

Fields of Study & Subjects

Asymmetric Hydrogenation and Catalysis Asymmetric Synthesis and Catalysis Catalytic C–H Functionalization Methods

Publication details

Journal / source
Chemical Science
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
20
Pages
10007–10014
Publication date
1 January 2026
Language
EN