Substrate-driven iridium photocatalysts enable diastereoselective dearomative polyoxygenation of hydroxyquinolines

Chemical Science 2026 Open access

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Authors: Andrea Uroz, Laura Blanco, Sergio Díaz‐Tendero, Claudia Feberero, Alba Collado, Silvia Cabrera, Jose Aleman
DOI: 10.1039/d6sc01835a
Cited by: 1
References: 43

Abstract

selective oxygen insertion into the coordinated quinoline, followed by water-assisted hydroxylation, yielding structurally complex polyoxygenated products. This substrate-driven approach eliminates the need for external photo-catalysts and demonstrates a unique strategy for the activation of heteroaromatic substrates, providing access to motifs of potential relevance in pharmaceuticals and functional materials. This work highlights how substrate-metal cooperation can be exploited to achieve transformations that are challenging or inaccessible with conventional photocatalytic systems.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Asymmetric Hydrogenation and Catalysis Oxidative Organic Chemistry Reactions

Publication details

Journal / source
Chemical Science
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
23
Pages
11346–11356
Publication date
1 January 2026
Language
EN