De novo design of NIR-II thioxanthene dye and phosphate-driven charge transfer-coupled J -aggregates for high resolution tumor angiography and type I phototherapy against hypoxic tumors

Chemical Science 2026 Open access

Read full text
Authors: Chuangli Zhang, Ziyong Wu, Yang Bai, Jing He, Mengyuan Miao, Feiyu DIAO, Qingzhi Wang, Shan Zhong, Pengfei Shi, Xinyue Song, Shusheng Zhang
DOI: 10.1039/d6sc01958g
Cited by: 1
References: 57

Abstract

-aggregates (P-SOH NPs), leading to a prominent redshift (beyond 350 nm) of absorption/emission to 1120/1134 nm, 36.1-fold fluorescence enhancement, 59.0-fold increased type I ROS yield, and PCE elevated to 51.1%. P-SOH NPs achieved NIR-II high-resolution tumor angiography (fluorescence resolution: 0.34 mm, signal-to-background ratio (SBR) = 4.56; photoacoustic resolution: 0.11 mm, SBR = 17.2). The type I phototherapy of P-SOH NPs maintained high tumor cell killing efficiency even in hypoxia, achieving complete tumor ablation.

Fields of Study & Subjects

Nanoplatforms for cancer theranostics Cancer Hypoxia and Metabolism Photodynamic Therapy Research Studies

Publication details

Journal / source
Chemical Science
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
30
Pages
14664–14681
Publication date
1 January 2026
Language
EN