Incorporation and properties of the tris -fluoromethylated motif into heterocycles, amino acids and analogues of elexacaftor and tezacaftor

Chemical Science 2026 Open access

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Authors: Josephine Stewart, Bruno A Piscelli, David B. Cordes, Rodrigo A. Cormanich, David O’Hagan

DOI: 10.1039/d6sc04239b

Cited by: 1

References: 75

Abstract

C- made the molecule more lipophilic indicating that the polarity induced by three fluorines is not sufficient to outcompete an OH group.

Fluorine in Organic Chemistry Chemical Reactions and Isotopes Nicotinic Acetylcholine Receptors Study

References 75