Trifluoromethylation of pyridines through skeletal rearrangement

Chemical Science 2026 Open access

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Authors: Haiwen Wang, Nilanjan Bhaduri, Michael F. Greaney
DOI: 10.1039/d6sc04438g
Cited by: 1
References: 42

Abstract

Et at the pyridine C2 position. The process enables highly selective C2 over C4 trifluoromethylation of pyridines, a reaction that challenges conventional Minisci methods. Sequential functionalisation of the Zincke intermediate is further demonstrated, to access triply-substituted pyridine products from mono-substituted starting materials.

Fields of Study & Subjects

Fluorine in Organic Chemistry Synthesis and Characterization of Pyrroles Advanced Synthetic Organic Chemistry

Publication details

Journal / source
Chemical Science
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
29
Pages
14204–14210
Publication date
1 January 2026
Language
EN