Redox-responsive nanoparticles for enhanced mRNA delivery: a comprehensive review
Abstract
, disulfide, diselenide, and polysulfide), carrier type, and NP architecture to key biological outcomes, including endosomal escape, redox responsiveness, transfection efficiency, and biodistribution. We further identify critical translational challenges-such as tumor redox heterogeneity, insufficient systematic preclinical evaluation, and manufacturing constraints-and propose actionable strategies, including multi-stimulus-responsive systems, microfluidic and process-analytical manufacturing, and formulation approaches to improve efficacy, reproducibility, and stability. Collectively, these insights provide a practical framework to guide the rational design and clinical translation of next-generation redox-responsive mRNA delivery platforms.
Fields of Study & Subjects
RNA Interference and Gene Delivery
Advanced Drug Delivery Systems
Nanoparticle-Based Drug Delivery
Publication details
- Journal / source
- Journal of Materials Chemistry B
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 14
- Issue
- 15
- Pages
- 4546–4570
- Publication date
- 1 January 2026
- Language
- EN