Dual-targeting sepsis-associated inflammation and infection using linoleic acid-based lipid–polymer hybrid nanoparticles

Journal of Materials Chemistry B 2026 Open access

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Authors: Abdelrahman Tageldin, Calvin A. Omolo, Vincent Obaga Nyandoro, Mohammed A. Gafar, Eman A. Ismail, Lucy Kiruri, Bongani Nkambule, Irene Mackraj, Thirumala Govender
DOI: 10.1039/d6tb00207b
Cited by: 1
References: 62

Abstract

antibacterial performance compared to bare VCM, along with significant antioxidant and anti-inflammatory activity, in LPS-stimulated macrophages. In a murine MRSA-induced sepsis model, treatment with VCM-LIN-P2O NPs resulted in marked bacterial clearance from major organs and the bloodstream, accompanied by a significant reduction in TNF-α, IL-1β, and IL-18 levels, thereby alleviating organ damage. Therefore, these findings establish VCM-LIN-P2O NPs as a promising multifunctional nanoplatform for targeted antibiotic delivery and effective sepsis therapy.

Fields of Study & Subjects

Immune Response and Inflammation Antimicrobial agents and applications Sepsis Diagnosis and Treatment

Publication details

Journal / source
Journal of Materials Chemistry B
Publisher
Royal Society of Chemistry (RSC)
Volume
14
Issue
21
Pages
6681–6701
Publication date
1 January 2026
Language
EN