Eggshell-derived nanoparticles accelerate wound healing
Abstract
experiments, including MTT assay, thymidine incorporation assay, cell cycle and apoptosis assay, ROS generation, and immunocytochemical analysis, were performed in human keratinocytes (HaCaT cells) to support the wound healing properties of ES-NP. We then validated the wound healing activity of ES-NP in a pre-clinical mouse (C57BL/6) model, where treatment with ES-NP significantly accelerated wound closure compared with the untreated control. The results are supported by histopathology (H&E staining), immunohistochemistry (Ki-67 and CD31/PECAM), and Masson's trichome staining (collagen deposition) of mouse skin tissue. Altogether, our findings suggest that ES-NP could be potential candidate for the treatment of wounds (acute and chronic) and other diseases where angiogenesis plays an important role.
Fields of Study & Subjects
Wound Healing and Treatments
Silk-based biomaterials and applications
Nanocomposite Films for Food Packaging
Publication details
- Journal / source
- Journal of Materials Chemistry B
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 14
- Issue
- 20
- Pages
- 6323–6342
- Publication date
- 1 January 2026
- Language
- EN