Synthesis and characterization of an injectable telechelic material for the epiretinal delivery of retinal gene therapies

Journal of Materials Chemistry B 2026 Open access

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Authors: James H. Westbay, Daniel P. Bigley, Sushma Sappa, Anfisa Ayalon, Hamzah Aweidah, Lauren D. Dignam, Joseph Nissim Martel, William A. Beltran, José‐Alain Sahel, Leah C. Byrne, Morgan V. Fedorchak
DOI: 10.1039/d6tb00267f
Cited by: 0
References: 62

Abstract

and may prove useful in other delivery applications. This is the first report of an injectable material that can be facilely loaded with retinal gene therapies. The results presented here are a crucial preliminary step in advancing a materials-based strategy for administering gene therapies to the retina.

Fields of Study & Subjects

Advanced Drug Delivery Systems RNA Interference and Gene Delivery Retinal Development and Disorders

Publication details

Journal / source
Journal of Materials Chemistry B
Volume
14
Issue
12
Pages
3703–3718
Publication date
1 January 2026
Language
EN