Sugar-coated immunometabolism: functionalized biomaterials as metabolic regulators of immune responses
Abstract
, hyaluronic acid, heparin) engage distinct immune receptors to induce targeted metabolic reprogramming in macrophages, dendritic cells, and other innate effectors. This minireview synthesizes recent breakthroughs in the field, elucidating how distinct sugar classes reshape immunometabolism by modulating glycolysis, oxidative phosphorylation, fatty acid metabolism, and associated inflammatory pathways and highlighting their translational applications in precision medicine. We discuss design considerations for sugar-functionalized scaffolds and outline future directions centered on precision glycoengineering, integrated metabolic analyses, and personalized therapeutic platforms.
Fields of Study & Subjects
Supramolecular Self-Assembly in Materials
Nanoplatforms for cancer theranostics
Graphene and Nanomaterials Applications
Publication details
- Journal / source
- Journal of Materials Chemistry B
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 14
- Issue
- 21
- Pages
- 6480–6493
- Publication date
- 1 January 2026
- Language
- EN