Nano-primed reprogrammed neurons suppress the glial scar and facilitate axonal regeneration after spinal cord injury
Abstract
, the composite scaffold ensured long-term graft retention, increasing rat survival to 100%. At 8 weeks post-SCI, treated rats exhibited remarkable motor recovery and gait correction. Histology demonstrated significant glial scar attenuation and robust regeneration of NF200-positive nerve fibers bridging the lesion. The integration of sustained release from nanoparticles and a biomimetic hydrogel effectively mitigates the toxicity of small molecules and ensures robust cell engraftment. This strategy effectively remodels the pathological microenvironment, promotes axon regeneration, and restores motor function, providing a promising and comprehensive therapeutic approach for severe SCI.
Fields of Study & Subjects
Nerve injury and regeneration
Pluripotent Stem Cells Research
Graphene and Nanomaterials Applications
Publication details
- Journal / source
- Journal of Materials Chemistry B
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 14
- Issue
- 21
- Pages
- 6606–6623
- Publication date
- 1 January 2026
- Language
- EN