The multifaceted roles of receptor tyrosine pseudokinases in cellular signalling

Biochemical Society Transactions 2026 Open access

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Authors: Emily C. Park, Andrew P. Thompson, James M. Murphy, Lung‐Yu Liang, Isabelle S. Lucet
DOI: 10.1042/bst20260770
Cited by: 1
References: 121

Abstract

Receptor tyrosine pseudokinases comprise approximately 10% of the receptor tyrosine kinase family and lack phosphotransferase activity due to substitutions of essential catalytic residues within their kinase folds. This review critically examines the eight human receptor tyrosine pseudokinases: EphA10, EphB6, HER3, PTK7, ROR1, ROR2, RYK, and STYK1. By reconciling recent structural and functional data, we highlight the diverse non-catalytic mechanisms these pseudokinases employ in cellular communication. This comprehensive analysis provides insights into non-canonical signalling pathways and highlights potential for therapeutic opportunities in diseases associated with pseudokinase dysfunction.

Fields of Study & Subjects

Axon Guidance and Neuronal Signaling Angiogenesis and VEGF in Cancer Wnt/β-catenin signaling in development and cancer

Publication details

Journal / source
Biochemical Society Transactions
Publisher
Portland Press Ltd.
Volume
54
Issue
6
Pages
727–743
Publication date
1 June 2026
Language
EN