Antidiabetic Potency of Pulutan (Urena lobata) Leaf Fraction and its Molecular Docking Analysis

Urena lobata is medicinal plant used to cure Diabetes mellitus traditionally. However, the phytoconstituent regulating blood glucose levels and their mechanism remain unexlpored. The study aim to evaluate antidiabetic potency of U.lobata leaf fractions. Ethanol solvent is used to extract U. lobata leaf by kinetic maceration methods therefore the concentrated extract was fractionated using n-hexane (Fraction A), n-butanol (Fraction B) and aqueous solvent (Fraction C) respectively. The anti-diabetic potency U.lobata was examined by oral glucose tolerance test. Blood glucose level of rat were measured after loading of glucose at the certain time and Area Under Curve (AUC) integrated were calculated using trape zoidal methods. Data was analyzed using one way ANOVA and continued with LSD test (p