Fabrication and Characterization of SPIONs for Drug Loading and Release Applications

Superparamagnetic iron oxide nanoparticles (SPIONs) were synthesized for metformin and probiotic drug delivery agents. In this work, the lattice parameter of SPIONs formation was 8.351, constructing an inverse spinel cubic with a crystallite size of 10.18 nm, respectively. The SPIONs formation was also detected by the presence of Fe–O functional groups, which were Fe-O tetrahedral and octahedral functional groups at 625– 700 cm–1 and 418–500 cm–1, respectively. In this experiment, SPIONs exhibited spherical particles with a size of 35.12 nm and presented superparamagnetic character with a saturation magnetization of 41.45 emu/g. Interestingly, SPIONs exhibited loading activity for metformin and probiotics with loading efficiencies of 67.51% and 80.67%, respectively.