Chondrosarcoma arising from long-standing Dysplasia Epiphysealis Hemimelica of the proximal humerus: A case report

SICOT-J 2026 Open access

Read full text
Authors: Stavropoulos Nj, Dimitra P. Papagelopoulos, Olympia Papakonstantinou, P Korkolopoulou, Eleftheria Lakiotaki, Panayiotis J. Papagelopoulos
DOI: 10.1051/sicotj/2025057
Cited by: 1
References: 3

Abstract

Dysplasia Epiphysealis Hemimelica (DEH), or Trevor's disease, is a rare, nonhereditary skeletal disorder involving abnormal cartilaginous overgrowth of the epiphysis. To our knowledge, malignant transformation has not been previously documented. We report a unique case of chondrosarcoma arising from a DEH lesion in the proximal humerus nearly 30 years after the initial diagnosis. The patient was treated with wide resection and reconstruction using a proximal humeral replacement with a reverse-constrained total shoulder arthroplasty. This case highlights the need for long-term follow-up in patients with DEH, especially when new symptoms suggest possible malignant transformation.

Fields of Study & Subjects

Bone Tumor Diagnosis and Treatments Musculoskeletal synovial abnormalities and treatments Connective tissue disorders research

Publication details

Journal / source
SICOT-J
Publisher
EDP Sciences
Volume
12
Pages
5–5
Publication date
1 January 2026
Language
EN