The Roles of A Proliferation-Inducing Ligand (APRIL) and B-Cell Activating Factor (BAFF) in IgA Nephropathy
Abstract
In IgA nephropathy (IgAN), elevated levels of the circulating autoantigen galactose-deficient IgA1 are critical to disease pathogenesis. Abnormal B-cell glycosylation pathways produce the autoantigen that, on recognition by autoantibodies, forms immune complexes. Genetic as well as in vitro, in vivo, and human immunologic studies have identified APRIL (a proliferation-inducing ligand) and BAFF (B-cell activating factor) as key cytokines controlling B-cell development and the differentiation of antibody-secreting cells. Targeting APRIL with or without BAFF is emerging as a viable strategy for the treatment of IgAN and nascent data from global clinical trials are showing very promising results.
Fields of Study & Subjects
Renal Diseases and Glomerulopathies
Renal Transplantation Outcomes and Treatments
Chronic Kidney Disease and Diabetes
Publication details
- Journal / source
- American Journal of Kidney Diseases
- Publisher
- Elsevier BV
- Volume
- 87
- Issue
- 5
- Pages
- 709–715
- Publication date
- 5 March 2026
- Language
- EN