Long-Term, Prospective Assessment of Cancer Risk in APC c.3920T>A (I1307K) Carriers: Evidence From a Cohort of Over 21,000 Healthy Individuals

Gastroenterology 2026 Open access

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Authors: Yael Hoffman, Audelia Eshel Fuhrer, Michal Levy, Diana Kazanov, Nadir Arber, Shiran Shapira
DOI: 10.1053/j.gastro.2025.10.027
Cited by: 2
References: 9

Abstract

The adenomatous polyposis coli (APC) gene, first identified and cloned in the early 1990s, functions as a key tumor suppressor, particularly in the context of familial adenomatous polyposis (MIM: 175100).1 Familial adenomatous polyposis is an autosomal dominant syndrome characterized by the development of hundreds to thousands of colonic adenomas, many of which progress to colorectal cancer (CRC). The disorder is typically caused by pathogenic APC mutations leading to truncated or nonfunctional protein products.

Fields of Study & Subjects

Economic and Financial Impacts of Cancer Occupational and environmental lung diseases Nutrition and Health in Aging

Publication details

Journal / source
Gastroenterology
Publisher
Elsevier BV
Volume
170
Issue
4
Pages
826–828
Publication date
10 February 2026
Language
EN