Hepatocellular Carcinoma – from Immunobiology to Immunotherapy
Abstract
Hepatocellular Carcinoma (HCC) is an entity characterized by a highly heterogenous tumor immune microenvironment. The introduction of immune checkpoint inhibitor (ICI) therapy as standard of care in advanced disease stages and with promising results in earlier stages has highlighted the need for a better understanding of the underlying immunobiology. In this review, we provide a summary about the immune landscape in HCC and discuss novel potential therapeutic targets as well as how spatial immune profiling may help identify optimal candidates for ICI therapy.
Fields of Study & Subjects
Hepatocellular Carcinoma Treatment and Prognosis
Cancer Immunotherapy and Biomarkers
Cholangiocarcinoma and Gallbladder Cancer Studies
Publication details
- Journal / source
- Zeitschrift für Gastroenterologie
- Publisher
- Georg Thieme Verlag KG
- Volume
- 64
- Issue
- 01
- Pages
- 67–83
- Publication date
- 1 January 2026
- Language
- DE