Successful endoscopic submucosal dissection of a large laterally spreading tumor in distal jejunum by the water pressure method using a newly developed double-balloon enteroscope

Despite advances in therapeutic endoscopy, reports of endoscopic resection in the small intestine remain extremely limited, and only a few cases of endoscopic submucosal dissection (ESD) for proximal small intestinal lesions without deep intubation have been reported [ 1 ]. Here, we present a case of distal jejunal ESD performed using a newly developed double-balloon enteroscope ([ Video 1 ]). Download Video Successful endoscopic submucosal dissection of a large laterally spreading tumor in the distal jejunum by the water pressure method using a newly developed double-balloon enteroscope.Video 1 A man in his fifties with familial adenomatous polyposis was found to have a large tumor in the small intestine. He had a history of total colectomy for rectal cancer. Because of the lesion size, we performed ESD using a double-balloon enteroscope (EN-840T, Fujifilm, Tokyo, Japan). The enteroscope was inserted trans-orally and advanced to the distal jejunum in the pelvis, where a 50-mm laterally spreading tumor was identified. Submucosal injection of hyaluronic acid was initiated from the distal side, followed by complete circumferential mucosal incision. Submucosal dissection was then attempted; however, it was extremely difficult due to poor maneuverability from prior surgery and the narrow submucosal space. Therefore, the enteroscope was withdrawn, and a small-caliber transparent hood (ST hood: DH-33GR, Fujifilm) was attached ([ Fig. 1 ], [ Fig. 2 ]). The water jet function was then applied for the water pressure method (WPM), which facilitated entry into the narrow submucosal space ([ Fig. 3 ]) [ 2 ] [ 3 ]. Repeated balloon assisted re-positioning also stabilized maneuverability. Finally, en bloc resection was successfully achieved in 263 minutes without perforation, and the mucosal defect was completely closed with clips ([ Fig. 4 ], [ Fig. 5 ]). The postoperative course was uneventful except for mild pancreatitis, which resolved conservatively, and the patient was discharged on postoperative day 6. Fig. 1 Appearance of the double-balloon enteroscope with the energy device in place. The energy device used for jejunal ESD was the ORISE 1.5-mm ProKnife (Boston Scientific Japan, Tokyo, Japan). ESD, endoscopic submucosal dissection. Fig. 2 The tip of the double-balloon enteroscope. The ST-hood was modified by cutting off the rubber part and then attached to the tip of the enteroscope, and the balloon tip of the enteroscope also functioned without issues. Fig. 3 Amber-red color imaging (ACI) during the ESD with the water pressure method. ACI enhances the visualization of the dissection plane within the very thin submucosal layer. Fig. 4 A white light image and an abdominal radiography after complete suturing of the mucosal defect. The mucosal defect was completely closed by the origami method using endoscopic clips (SureClip; Boston Scientific Japan, Tokyo, Japan). The radiographic image indicates that the treated lesion was identified in the pelvis, and the procedure was completed without perforation. Fig. 5 A white light image of the specimen with indigo carmine. En-bloc resection was successfully achieved. Pathological diagnosis: Tubular adenoma, intestinal type, pHM0, and pVM0. To the best of our knowledge, this is the first successful case of distal jejunal ESD. The newly developed double-balloon enteroscope enabled access to the deep small intestine and, with the aid of the water jet function, facilitated precise submucosal dissection using WPM, thereby overcoming the technical difficulties of small intestinal ESD. Endoscopy_UCTN_Code_TTT_1AP_2AD Publication History Article published online: 08 January 2026 © 2026. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/). Georg Thieme Verlag KG Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany