Synthesis of Tetrahydroisoquinolinoquinolines via Sequential Pd-Catalyzed N-Arylation and Pd-Catalyzed Alkene Carboamination Reactions
Abstract
Abstract The synthesis of substituted tetrahydroisoquinolinoquinolines via a two-step route involving a Pd-catalyzed N-arylation reaction followed by a Pd-catalyzed alkene carboamination reaction is described. The combined transformations lead to the generation of two rings and three bonds (two C–N and one C–C) and the heterocyclic products are obtained in moderate to good yields.
Fields of Study & Subjects
Catalytic C–H Functionalization Methods
Synthesis and Biological Activity
Berberine and alkaloids research
Publication details
- Journal / source
- Synthesis
- Publisher
- Georg Thieme Verlag KG
- Volume
- 58
- Issue
- 08
- Pages
- 910–916
- Publication date
- 20 January 2026
- Language
- EN