Palladium-catalyzed Cyclization of 5-(o-Aminoaryl) 1,2,3-Triazoles with Isocyanides to Construct Triazolo [1,5-c]Quinazolines
Abstract
Abstract A series of triazoloquinazoline derivatives were synthesized by insertion cyclization of 5-(o-aminoaryl) 1,2,3-triazoles with isocyanides under palladium catalysis. This method features the construction of tricyclic-fused 1,2,3-triazoles involving two C–N bond formations in one simple manipulation. The system is suitable for a variety of 1,2,3-triazoles and isocyanides with good functional group compatibility, and even for other types of nitrogen-containing heterocyclic compounds such as 1,2,4-triazole, pyrazole, tetrazole, imidazole, and indole.
Fields of Study & Subjects
Click Chemistry and Applications
Catalytic Cross-Coupling Reactions
Quinazolinone synthesis and applications
Publication details
- Journal / source
- Synlett
- Volume
- 37
- Issue
- 04
- Pages
- 499–502
- Publication date
- 13 January 2026
- Language
- EN