An Expeditious Synthesis of 2-C-Cyanoglycals
Abstract
Abstract An efficient conversion of 2-C-formyl glycals to the corresponding 2-C-cyanoglycals is achieved using azidotrimethylsilane in the presence of catalytic trimethylsilyl trifluoromethanesulfonate. The generality of the reaction is evaluated by applying it to a number of differently protected 2-C-formyl glycals. The methodology features protecting group tolerance, prompt conversion, and excellent yields.
Fields of Study & Subjects
Carbohydrate Chemistry and Synthesis
Click Chemistry and Applications
Chemical Synthesis and Analysis
Publication details
- Journal / source
- Synlett
- Volume
- 37
- Issue
- 07
- Pages
- 899–903
- Publication date
- 8 January 2026
- Language
- EN