Synthesis of the Pentasaccharide Repeating unit Corresponding to the Cell-wall O-antigenic Polysaccharide of Oral Bacteria Porphyromonas circumdentaria NCTC 12469
Abstract
Abstract A concise chemical synthetic strategy has been developed for the synthesis of the pentasaccharide repeating unit of the cell-wall O-antigen of Porphyromonas circumdentaria NCTC 12469, which plays an important role in the development of periodontal disease. Several regio- and stereoselective glycosylations were carried out with high yields and satisfactory stereochemistry at the glycosidic linkages using suitably functionalized thioglycoside intermediates as glycosyl donors.
Fields of Study & Subjects
Carbohydrate Chemistry and Synthesis
Organic Chemistry Synthesis Methods
Glycosylation and Glycoproteins Research
Publication details
- Journal / source
- Synthesis
- Volume
- 58
- Issue
- 06
- Pages
- 691–696
- Publication date
- 16 January 2026
- Language
- EN