Pd(II)-Catalyzed Highly Atroposelective C–H Alkynylation of [n]Paracyclophanes
Abstract
Abstract Optically pure alkynyl-containing molecules represent highly versatile synthons in organic synthesis. Herein, we report a Pd/pGlu-catalyzed enantioselective C–H alkynylation of [n]paracyclophanes. This method provides efficient access to a diverse range of alkynylated [n]paracyclophanes in high yields with excellent enantioselectivities. Additionally, a cyclophane-based bifunctional thiourea catalyst was synthesized and exhibited promising activity in asymmetric Michael additions. Thermal epimerization studies were further conducted to elucidate the correlation between conformational stability and structural parameters.
Fields of Study & Subjects
Axial and Atropisomeric Chirality Synthesis
Catalytic C–H Functionalization Methods
Asymmetric Synthesis and Catalysis
Publication details
- Journal / source
- Synthesis
- Volume
- 58
- Issue
- 08
- Pages
- 865–872
- Publication date
- 27 January 2026
- Language
- EN