Efficacy and Safety of Hypertrophy Induction by Portal Vein Embolization with PVA Particles and Iodinated Oil: A Single Center Study with 103 Patients

Purpose: The aim of this study was to investigate the effectiveness of hypertrophy induction by portal vein embolization (PVE) using polyvinyl alcohol particles (PVA) and iodinated oil. Materials and Methods: Hypertrophy induction after portal vein embolization with PVA particles and iodinated oil was analyzed in 103 patients between August 2009 and June 2023. Technical success, hypertrophy success, and complication rate were evaluated and compared to other common procedures. To the best of our knowledge, this is the largest single-center study conducted with special regard to this combined embolization technique. Results: Overall, a technical success of 99% (n = 102 patients) could be achieved. Following portal vein embolization using PVA particles and iodinated oil, hypertrophy was attained with a hypertrophy success of 99% as well. The determined pre-interventional standardized future liver remnant (sFLR) was 21% and the post-interventional sFLR 29.8%. Within an interval of 31 d, a degree of hypertrophy (DH) of 7.3% and a KGR of 0.22%/d (approximately 1.51%/week) were achieved. Complications in the context of portal vein embolization occurred within 16.5% (n = 17) of all patients. Nine patients were affected by minor complications. Major complications were documented in eight patients. Mortality directly related to portal vein embolization was 0%. Conclusion: Embolization using PVA particles and iodinated oil is a safe and promising method for inducing hypertrophy in locally advanced liver disease. Key Points: · PVE with PVA particles and iodinated oil is a viable procedure.. · Significant hypertrophy is achieved with this method.. · The procedure mentioned here has a low periinterventional complication rate.. · Findings are supported by a large single-center study.. Citation Format: · Schlei J, Westphale S, Thurner A et al. Efficacy and Safety of Hypertrophy Induction by Portal Vein Embolization with PVA Particles and Iodinated Oil: A Single Center Study with 103 Patients. Rofo 2026; DOI 10.1055/a-2781-8813.