An Update on the Total Synthesis of (S)-Quisqualic Acid and Its Derivatives
Abstract
Abstract (S)-Quisqualic acid and its structural analogues show potent activity across various fields of medicine. The growing interest in this amino acid family creates a pressing need for detailed synthetic procedures. Here, we present a comprehensive synthesis of N-Boc-(S)-quisqualic acid from l-serine with an overall yield of 58% over six steps. Further transformation into the C-protected (S)-quisqualic acid and the unprotected (S)-quisqualic acid HCl salt is also feasible with good yields. The complete characterization (NMR, HRMS, IR) of the intermediates and target molecules allows the reliable utilization of this synthetic work.
Fields of Study & Subjects
Plant biochemistry and biosynthesis
Synthetic Organic Chemistry Methods
Phosphorus compounds and reactions
Publication details
- Journal / source
- Synthesis
- Volume
- 58
- Issue
- 07
- Pages
- 811–816
- Publication date
- 8 January 2026
- Language
- EN