K2S2O8-KI Cooperative Oxidative System for Direct C3-Sulfenylation of Indoles with Thiols and Disulfides
Abstract
Abstract A mild and metal-free method for the direct C3-sulfenylation of indoles using a KI/K2S2O8 oxidative system has been developed. The reaction proceeds efficiently in MeCN/H2O at 60 °C, affording 3-sulfenylindoles in up to 95% yield without the need for transition metals or bases. A wide range of indole derivatives and aromatic sulfenylating agents bearing electron-donating or electron-withdrawing substituents are well tolerated. This protocol provides an efficient, scalable, and environmentally benign approach to the synthesis of 3-sulfenylindoles under simple operational conditions.
Fields of Study & Subjects
Sulfur-Based Synthesis Techniques
Synthesis of Indole Derivatives
Oxidative Organic Chemistry Reactions
Publication details
- Journal / source
- Synlett
- Volume
- 37
- Issue
- 08
- Pages
- 956–962
- Publication date
- 18 January 2026
- Language
- EN