Cp*Co(III)-Catalyzed Regioselective Redox-Neutral Synthesis of 3-Alkenylated Isoquinolones from N-Chlorobenzamides with 1,3-Diynes at Room Temperature
Abstract
Abstract We have developed Cp*Co(III)-catalyzed redox-neutral synthesis of 3-alkynylated isoquinolones via (4 + 2) annulation of N-chlorobenzamides and 1,3-diynes. The reaction displayed a broad scope and functional group tolerance and performed under mild conditions at room temperature. The high regioselectivity was observed in case of meta-substituted N-chlorobenzamides as compared to our previously developed Ru-catalytic system. The reaction is operationally simple and also applicable to the broad range of substrates with good functional group tolerance.
Fields of Study & Subjects
Catalytic Alkyne Reactions
Catalytic C–H Functionalization Methods
Catalytic Cross-Coupling Reactions
Publication details
- Journal / source
- Synlett
- Volume
- 37
- Issue
- 10
- Pages
- 1135–1140
- Publication date
- 3 February 2026
- Language
- EN