Highlights of Pd-Catalyzed Reactions of Alkynes Involving C–H Functionalization: Synthesis of Acyclic, Carbo-, and Heterocyclic Compounds Installed with Alkyne Unit
Abstract
Abstract The review discusses the utility of C–H functionalization approaches involving alkynes, which act as multifaceted coupling partners due to their unsaturation property, small size, and potential to participate in multiple reaction pathways, such as annulations, alkylation, alkenylation, alkynylation and Catellani reaction. The review emphasizes the investigation of palladium catalysis for these transformations. It highlights the developments in Pd-catalyzed C–H functionalization-based synthesis of simple and complex carbo- and heterocyclic compounds, as well as biologically active and alkynyl-functionalized molecules.
Fields of Study & Subjects
Catalytic C–H Functionalization Methods
Catalytic Cross-Coupling Reactions
Catalytic Alkyne Reactions
Publication details
- Journal / source
- Synthesis
- Volume
- 58
- Issue
- 11
- Pages
- 1199–1237
- Publication date
- 27 January 2026
- Language
- EN