Catalyst-Free Alkylation of Quinoxalines in Water
Abstract
Abstract A catalyst-free nucleophilic allylation of quinoxalines in water has been developed, enabling efficient synthesis of versatile, functionalized C3-alkylated quinoxalin-2(1H)-ones. This method selectively activates the imine moiety through hydrogen-bonding interactions, shunning conventional strategies that require transition metals, photoirradiation, or elevated temperatures. Remarkably, the reaction exhibits accelerated kinetics in water, due to strong hydrogen-bonding effects that facilitate reactant aggregation.
Fields of Study & Subjects
Synthesis and Biological Evaluation
Multicomponent Synthesis of Heterocycles
Catalytic Alkyne Reactions
Publication details
- Journal / source
- Synlett
- Volume
- 37
- Issue
- 06
- Pages
- 734–738
- Publication date
- 27 January 2026
- Language
- EN