Sodium-Lump-Mediated Mechanochemical Deprotection of Benzyl-Derived Groups
Abstract
Abstract This study demonstrates the facile removal of benzyl-derived protecting groups via ammonia-free, mechanochemically driven Birch reduction using inexpensive and easy-to-handle sodium lumps. Various benzyl-protected alcohols and amines were efficiently deprotected within 30 min. Notably, all synthetic operations can be performed without inert gases or bulk solvents.
Fields of Study & Subjects
Advanced Synthetic Organic Chemistry
Coordination Chemistry and Organometallics
Chemical Synthesis and Reactions
Publication details
- Journal / source
- Synthesis
- Volume
- 58
- Issue
- 10
- Pages
- 1161–1164
- Publication date
- 29 January 2026
- Language
- EN