Synthesis of 4-Sulfenyl-Isocoumarins via Thio-Annulation of 2-Alkynyl-benzonate with RSCl: In Situ Preparation using Disulfides and HCl/HNO3

Synthesis 2026

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Authors: Li Lu Ting, xiaocheng huang, Zhixiang Yao, Hui Su, Yuexin Yang
DOI: 10.1055/a-2802-6034
Cited by: 0
References: 77

Abstract

Abstract We have developed a novel and metal-free method to construct the derivatives of 4-sulfenyl isocoumarins via thio-annulation of 2-alkynyl benzoates with sulfenyl chlorides which is in situ prepared by disulfides and HCl/HNO3. The reaction shows high functional group tolerance and can be scaled up to the gram-scale with less loss in yield. Both sulfide groups of the disulfide reagent were used in the reaction.

Fields of Study & Subjects

Sulfur-Based Synthesis Techniques Synthesis and Reactivity of Sulfur-Containing Compounds Catalytic Alkyne Reactions

Publication details

Journal / source
Synthesis
Volume
58
Issue
11
Pages
1270–1278
Publication date
2 February 2026
Language
EN