Meta-Analysis of Mortality Patterns in ANCA-Associated Vasculitis Across Regions, Sex, and Subtypes
Abstract
Abstract To evaluate all-cause and cause-specific standardized mortality ratios (SMRs) in patients with ANCA-associated vasculitis (AAV) using meta-analyses stratified by sex, geographic region, and disease subtype. A comprehensive systematic review was conducted using the Medline, Embase, and Web of Sciences databases from inception to April 2025. Meta-analyses were performed to assess all-cause, sex-specific, region-specific, disease-specific, and cause-specific SMRs. Twenty-two studies comprising 8,749 AAV patients and 2,503 deaths were included in the meta-analysis. Overall all-cause SMR was significantly elevated in AAV patients compared with the general population (SMR: 2.477, 95% CI: 2.028–3.026, p
Fields of Study & Subjects
Vasculitis and related conditions
Renal Diseases and Glomerulopathies
Systemic Lupus Erythematosus Research
Publication details
- Journal / source
- Aktuelle Rheumatologie
- Volume
- 51
- Issue
- 02
- Pages
- 106–115
- Publication date
- 12 March 2026
- Language
- DE