Hydrosilane-Promoted Dehalogenation of Heteroaryl Halides under Air Conditions

Synlett 2026

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Authors: Pengfei Yu, Xian-liang Zhao, Luyi Chen, Zhihao Zhou, Chang Zhao
DOI: 10.1055/a-2809-7904
Cited by: 6
References: 28

Abstract

Abstract An efficient dehalogenation reaction of α-substituted halogenated heterocycles catalyzed by Pd/C with triethylsilane (TES) was developed. This study explores the catalytic dehalogenation of N-heteroaryl halides using a Pd/C-K2CO3 system, with TES serving as the hydrogen source under air conditions (air and moisture). The reaction conditions are compatible with various functional groups with good to excellent yields.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Catalytic Cross-Coupling Reactions Environmental remediation with nanomaterials

Publication details

Journal / source
Synlett
Publisher
Georg Thieme Verlag KG
Volume
37
Issue
08
Pages
987–990
Publication date
10 February 2026
Language
EN