Activating Highly Hindered Anhydrides for Use in Masking Alcohols and Polyols – A New Method Inspired by Cationic Palladium

Synlett 2026

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Authors: Enoch A. Mensah, Sabet-LeBlanc Jasmine, Elizabeth A. Davis, Jordan Christopher Conard
DOI: 10.1055/a-2822-9058
Cited by: 0
References: 49

Abstract

Abstract A new method inspired by cationic palladium (II) species in activating highly hindered acid anhydrides in masking alcohols and polyols is described. This protocol utilizes a cationic palladium catalyst Pd(PhCN)2(OTf)2 generated in situ from Pd(PhCN)2Cl2 and AgOTf to activate highly hindered acid anhydrides and to direct the acylation process. This new method is highly efficient and proceeds with only 1 mol% of the catalyst loading at mostly room temperature. The method has a wide substrate scope in masking different alcohols and polyols with robust protecting groups in good to excellent yields.

Fields of Study & Subjects

Catalytic Cross-Coupling Reactions Chemical Synthesis and Reactions Oxidative Organic Chemistry Reactions

Publication details

Journal / source
Synlett
Volume
37
Issue
09
Pages
1055–1060
Publication date
26 February 2026
Language
EN